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2012
Verbeek, J., Syvänen, S., Schuit, R.C., Eriksson, J., de Lange, E.C., Windhorst, A.D., Luurtsema, G., Lammertsma, A.A. , Synthesis and preclinical evaluation of [(11)C]D617, a metabolite of (R)-[(11)C]verapamil, Nucl Med Biol. DOI
2011
Syvänen, S., de Lange, E.C., Tagawa, Y., Schenke, M., Molthoff, C.F., Windhorst, A.D., Lammertsma, A.A., Voskuyl, R.A. , Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods, Neuroimage, vol. 57, no. 3, pp. 928-37. DOI
Syvänen, S., Luurtsema, G., Molthoff, C.F., Windhorst, A.D., Huisman, M.C., Lammertsma, A.A., Voskuyl, R.A., de Lange, E.C. , (R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus, BMC Med Imaging, vol. 11, pp. 1. DOI
2010
van Steeg, T.J., Krekels, E.H., Freijer, J., Danhof, M., de Lange, E.C. , Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)), J Pharm Sci, vol. 99, no. 5, pp. 2511-20. DOI
Stevens, J., van den Berg, D.J., de Ridder, S., Niederlander, H.A., van der Graaf, P.H., Danhof, M., de Lange, E.C. , Online solid phase extraction with liquid chromatography-tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples, J Chromatogr B Analyt Technol Biomed Life Sci, vol. 878, no. 13-14, pp. 969-75. DOI
2009
Stevens, J., Suidgeest, E., van der Graaf, P.H., Danhof, M., de Lange, E.C. , A New Minimal-Stress Freely-Moving Rat Model for Preclinical Studies on Intranasal Administration of CNS Drugs, Pharm Res. DOI
Cremers, T. I, de Vries, M.G., Huinink, K.D., van Loon, J.P., v d Hart, M., Ebert, B., Westerink, B.H., De Lange, E.C. , Quantitative microdialysis using modified ultraslow microdialysis: direct rapid and reliable determination of free brain concentrations with the MetaQuant technique, J Neurosci Methods, vol. 178, no. 2, pp. 249-54. DOI
2008
Ravenstijn, P.G., Merlini, M., Hameetman, M., Murray, T.K., Ward, M.A., Lewis, H., Ball, G., Mottart, C., de Ville Goyet, C., Lemarchand, T., van Belle, K., O'Neill, M.J., Danhof, M., de Lange, E.C. , The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments, J Pharmacol Toxicol Methods, vol. 57, no. 2, pp. 114-30. DOI
van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model, J Pharmacol Exp Ther, vol. 324, no. 3, pp. 1234-42. DOI
Groenendaal, D., Freijer, J., Rosier, A., de Mik, D., Nicholls, G., Hersey, A., Ayrton, A.D., Danhof, M., de Lange, E.C. , Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics, Eur J Pharm Sci, vol. 34, no. 2-3, pp. 149-63. DOI
van Steeg, T.J., Boralli, V.B., Krekels, E.H., Slijkerman, P., Freijer, J., Danhof, M., de Lange, E.C. , Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach, J Pharm Sci. DOI
Danhof, M., de Lange, E.C., Della Pasqua, O.E., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research, Trends Pharmacol Sci, vol. 29, no. 4, pp. 186-91. DOI
2007
van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint, Br J Pharmacol, vol. 151, no. 3, pp. 356-66. DOI
van Steeg, T.J., Krekels, E.H., Danhof, M., de Lange, E.C. , Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats, J Pharmacol Toxicol Methods, vol. 56, no. 1, pp. 72-8. DOI
Groenendaal, D., Freijer, J., de Mik, D., Bouw, M.R., Danhof, M., de Lange, E.C. , Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG, Br J Pharmacol, vol. 151, no. 5, pp. 713-20. DOI
Groenendaal, D., Freijer, J., de Mik, D., Bouw, M.R., Danhof, M., de Lange, E.C. , Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux, Br J Pharmacol, vol. 151, no. 5, pp. 701-12. DOI
Danhof, M., de Jongh, J., De Lange, E.C., Della Pasqua, O., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis, Annu Rev Pharmacol Toxicol, vol. 47, pp. 357-400. DOI
Danhof, M., de Jongh, J., De Lange, E.C., Della Pasqua, O., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis, Annu Rev Pharmacol Toxicol, vol. 47, pp. 357-400. DOI
2005
2004
Luurtsema, G., de Lange, E.C., Lammertsma, A.A., Franssen, E.J. , Transport across the blood-brain barrier: stereoselectivity and PET-tracers, Mol Imaging Biol, vol. 6, no. 5, pp. 306-18. DOI
de Lange, E.C. , Potential role of ABC transporters as a detoxification system at the blood-CSF barrier, Adv Drug Deliv Rev, vol. 56, no. 12, pp. 1793-809. DOI
2002
Sills, G.J., Kwan, P., Butler, E., de Lange, E.C., van den Berg, D.J., Brodie, M.J. , P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice, Epilepsy Behav, vol. 3, no. 5, pp. 427-432. DOI
Karssen, A.M., Meijer, O.C., van der Sandt, I.C., De Boer, A.G., De Lange, E.C., De Kloet, E.R. , The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone, J Endocrinol, vol. 175, no. 1, pp. 251-60. DOI
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