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2012
Verbeek, J., Syvänen, S., Schuit, R.C., Eriksson, J., de Lange, E.C., Windhorst, A.D., Luurtsema, G., Lammertsma, A.A. , Synthesis and preclinical evaluation of [(11)C]D617, a metabolite of (R)-[(11)C]verapamil, Nucl Med Biol. DOI
2011
Syvänen, S., de Lange, E.C., Tagawa, Y., Schenke, M., Molthoff, C.F., Windhorst, A.D., Lammertsma, A.A., Voskuyl, R.A. , Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods, Neuroimage, vol. 57, no. 3, pp. 928-37. DOI
Syvänen, S., Luurtsema, G., Molthoff, C.F., Windhorst, A.D., Huisman, M.C., Lammertsma, A.A., Voskuyl, R.A., de Lange, E.C. , (R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus, BMC Med Imaging, vol. 11, pp. 1. DOI
2010
2009
Syvänen, S., Lindhe, O., Palner, M., Kornum, B.R., Rahman, O., Langstrom, B., Knudsen, G.M., Hammarlund-Udenaes, M. , Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport, Drug Metab Dispos, vol. 37, no. 3, pp. 635-43. DOI
2008
Syvänen, S., Hooker, A., Rahman, O., Wilking, H., Blomquist, G., Langstrom, B., Bergstrom, M., Hammarlund-Udenaes, M. , Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier, J Pharm Sci, vol. 97, no. 12, pp. 5386-400. DOI
Hammarlund-Udenaes, M., Friden, M., Syvänen, S., Gupta, A. , On the rate and extent of drug delivery to the brain, Pharm Res, vol. 25, no. 8, pp. 1737-50. DOI
Eriksson, O., Wallberg, A., Syvänen, S., Josephsson, R., Langstrom, B., Bergstrom, M. , A computerized infusion pump for control of tissue tracer concentration during positron emission tomography in vivo pharmacokinetic/pharmacodynamic measurements, BMC Med Phys, vol. 8, pp. 2. DOI
2007
Lundquist, P., Roman, M., Syvänen, S., Hartvig, P., Blomquist, G., Hammarlund-Udenaes, M., Langstrom, B. , Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats, Synapse, vol. 61, no. 6, pp. 440-9. DOI
Syvänen, S., Barletta, J., Blomquist, G., Langstrom, B., Bergstrom, M. , PET-evaluated transport of [11C]hydroxyurea across the rat blood-brain barrier--lack of influence of cyclosporin and probenecid, Drug Metab Lett, vol. 1, no. 3, pp. 189-94.
Syvänen, S., Eriksson, J., Genchel, T., Lindhe, O., Antoni, G., Langstrom, B. , Synthesis of two potential NK1-receptor ligands using [1-11C]ethyl iodide and [1-11C]propyl iodide and initial PET-imaging, BMC Med Imaging, vol. 7, pp. 6. DOI
2006
Syvänen, S., Blomquist, G., Sprycha, M., Hoglund, A.U., Roman, M., Eriksson, O., Hammarlund-Udenaes, M., Langstrom, B., Bergstrom, M. , Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET, Neuroimage, vol. 32, no. 3, pp. 1134-41. DOI
Syvänen, S., Blomquist, G., Appel, L., Hammarlund-Udenaes, M., Langstrom, B., Bergstrom, M. , Predicting brain concentrations of drug using positron emission tomography and venous input: modeling of arterial-venous concentration differences, Eur J Clin Pharmacol, vol. 62, no. 10, pp. 839-48. DOI
Bergstrom, M., Yates, R., Wall, A., Kagedal, M., Syvänen, S., Langstrom, B. , Blood-brain barrier penetration of zolmitriptan--modelling of positron emission tomography data, J Pharmacokinet Pharmacodyn, vol. 33, no. 1, pp. 75-91. DOI
Syvänen, S., Xie, R., Sahin, S., Hammarlund-Udenaes, M. , Pharmacokinetic consequences of active drug efflux at the blood-brain barrier, Pharm Res, vol. 23, no. 4, pp. 705-17. DOI